Mukesh Jain, MD, Chief Research Officer – UH Harrington Heart & Vascular Institute

Dr. Jain is Director of the Case Cardiovascular Research Institute at Case Western Reserve University, the Ellery Sedgwick Jr. Chair & Distinguished Scientist, Chief Scientific Officer, Harrington Discovery Institute, and Chief Research Officer, Harrington Heart & Vascular Institute at University Hospitals Cleveland Medical Center. He graduated summa cum laude from the University of Buffalo School of Medicine. He then completed his Internal Medicine residency at the Beth Israel Hospital, Harvard Medical School followed by a research fellowship at Harvard. Dr. Jain completed his Cardiovascular Medicine fellowship at Brigham and Women’s Hospital and then joined the faculty at from 2000-2006.  There he rose through the ranks and eventually became Director of the Program in Cardiovascular Transcriptional Biology at Harvard Medical School.
Dr. Jain is recognized for discovery of essential roles for the transcription factor family Krüppel-like factors (KLFs) in inflammation and metabolism. In addition, he has translated this corpus of work into animals and humans, thus implicating KLFs in the physiology of inflammatory and metabolic diseases including sepsis, myopathy, diabetes, and vascular dysfunction. As a direct result of this work, KLFs are now increasingly viewed, together with classic regulators such as NFkB and nuclear receptors, as nodal determinants of cellular inflammation and metabolism. 
 

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