Thursday, September 25, 2014
CLEVELAND – Two recently published studies by a research team at University Hospitals (UH) Case Medical Center Seidman Cancer Center have the potential to advance treatments for small cell lung cell cancer (SCLC). This aggressive form of lung cancer has seen no treatment advances in 30 years and “is a disease in urgent need of new drug therapies,” write the study’s authors.
“In small cell lung cancer, which impacts about 30-40,000 people each year in the United States, there has been no therapeutic progress and very little research,” says Afshin Dowlati, MD, lead author and Director of the Center for Cancer Drug Development at UH Seidman Cancer Center. “Additionally, there are no approved targeted therapies for the disease. These studies lay the foundation for future research aimed at finding important new treatments for this highly malignant cancer.”
A study titled, RET Mutation and Expression in Small Cell Lung Cancer, was published in the September issue of Journal of Thoracic Oncology and found a new mutation in SCLC which may play a role in the disease’s development. The researchers found that the genetic mutation, called RET (rearranged during transfection), was linked to rapid cell growth.