Neurological Institute

Wednesday, May 17, 2017

DAWN trial results demonstrate dramatic reduction in disability from stroke up to 24 hours of onset

CLEVELAND – Results from the DAWN stroke trial presented at the European Stroke Organization Conference (ESOC) provide compelling evidence that selected patients suffering a major ischemic stroke recovered significantly better with mechanical retrieval of the blood clot with medical therapy compared with medical therapy alone when initiated past the current guidelines of within 6 hours and up to 24 hours of the stroke.
University Hospitals Cleveland Medical Center was one of the top seven recruiting sites in the multi-site study that enrolled a total of 206 patients in the nation. The results showed that patients treated with the retrieval system, known as mechanical thrombectomy, had significantly decreased post-stroke disability and improved functional independence at 90 days compared to medical management alone.

Friday, April 28, 2017

Dr. Andrew Sloan presents encouraging results of Laser Interstitial Thermal Therapy (LITT) clinical studies for difficult-to-access brain lesions

CLEVELAND – Andrew Sloan, MD, Director of the Brain Tumor and NeuroOncology Center at University Hospitals Cleveland Medical Center, presented new data supporting use of the NeuroBlate system for brain lesions at the 2017 American Association of Neurological Surgeons (AANS) Annual Scientific Meeting in Los Angeles on April 26. 
Dr. Sloan, who is also Professor and Vice Chair of the Department of Neurosurgery at Case Western Reserve University School of Medicine, presented on Monteris Medical’s LAISE study results. He delivered an oral presentation titled “Laser Ablation in Stereotactic Neurosurgery (LAISE): A Multi-Institutional Retrospective Analysis of LITT for Glioma” which described the results of 97 patients whose lesions were ablated with the NeuroBlate system.
Of the lesions analyzed, 48 percent were deep-seated, 57.8 percent were considered inoperable, and 1 percent were not suitable for chemotherapy. 

Wednesday, March 29, 2017

University Hospitals Cleveland Medical Center physicians part of groundbreaking research of first report of quadriplegic man moving arm through brain-controlled muscle stimulation

CLEVELAND – A neurologist and two neurosurgeons from University Hospitals Cleveland Medical Center played vital roles in a new study reporting the first successful case in the world of a man with quadriplegia moving his paralyzed right arm through brain-controlled muscle stimulation.  
Using an implanted brain sensor array and muscle stimulators, the 56-year-old man, Bill Kochevar, who had a complete traumatic high spinal cord injury from a bicycle accident, was able to extend his arm, grasp a cup and bring it to his mouth.  In other tests, he was able to feed himself using a fork.
The major, multi-institutional study appears in the March 28 issue of the journal The Lancet. UH Neurological Institute physicians were part of the research team: Benjamin Walter, MD, Director of the UH Movement Disorders Program and the Clinical Principal Investigator for the study in Cleveland; Jonathan Miller, MD, Director of the Functional and Restorative Neurosurgery Center and lead surgeon, and neurosurgeon Jennifer Sweet, MD.

Friday, February 03, 2017

University Hospitals Rainbow Babies & Children’s Hospital opens first stem cell study in patients with cystic fibrosis

CLEVELAND – A 39-year-old man with cystic fibrosis (CF) made history by becoming the first person in the world to receive human adult stem cells in a new research study that researchers hope will someday lead to the development of a therapy to reduce the inflammation and infection caused by CF. 

The pioneering subject in the study is Bob Held from Alliance, Ohio, who received an infusion of cells called allogeneic human mesenchymal stem cells (hMSC), adult stem cells collected from the bone marrow of healthy volunteers.  Mr. Held was diagnosed with CF when he was 16 months old. 

Currently, there is no cure for CF, and life expectancy for patients who survive into adulthood is approximately 41 years of age.

Wednesday, October 12, 2016

UH Neurological Institute researchers part of neuroscience ‘big data’ grant

CLEVELAND – University Hospitals Cleveland Medical Center neurologists and a biostatistics researcher are part of a recently announced big data grant recently awarded to Case Western Reserve University School of Medicine by the National Science Foundation.
Samden Lhatoo, MD, Director of the UH Epilepsy Center, Martha Sajatovic, MD, Director of the UH Neurological and Behavioral Outcomes Research Center, and Curtis Tatsuoka, PhD, Director of Biostatistics in the UH Neurological Institute, will work with Principal Investigator Satya Sahoo, PhD, Assistant Professor of Medical Informatics in the Case Western Reserve Department of Epidemiology and Biostatistics.  Dr. Lhatoo is a Professor of Neurology and Dr. Sajatovic is a Professor of Psychiatry at Case Western Reserve School of Medicine.
Dr. Sahoo was awarded a three-year grant to help researchers more effectively gather, use, and share neuroscience-related data, ultimately leading to better treatments.  He will team with colleagues on using technology to obtain, study, and share large amounts of clinical, cognitive, demographic, genetic, and phenotypic (observable characteristics) data from research on neurologically related diseases, conditions and impairments, according to a news release from Case Western Reserve.  

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