Neurological Institute

Wednesday, October 05, 2016

Study reports innovative combination of minimally invasive procedures Laser Interstitial Thermotherapy (LITT) & ‘mini’ craniotomy for treating ‘inoperable’ brain tumors

CLEVELAND – A new paper in the October issue of the journal Neurosurgical Focus finds the use of laser beneficial for the removal of large, “inoperable” glioblastoma (GBM) and other types of brain tumors.  The paper is authored by Andrew Sloan, MD, and colleagues from University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine and Case Comprehensive Cancer Center.  (The paper can be found:  A video abstract about it can be found: )
Dr. Sloan and other investigators at the Case Comprehensive Cancer Center led the first in human trials, published in 2013, of a procedure with laser interstitial thermotherapy (LITT), a minimally invasive approach using a laser to “cook” a tumor through a tiny hole in the scalp and bone and the intra-operative MRI (iMRI) to fine tune the treatment rather than the surgeon’s direct vision.   

Wednesday, August 10, 2016

Phase 3 Alzheimer’s disease clinical trial for potential add-on therapy to Donepezil (Aricept) at University Hospitals

CLEVELAND — University Hospitals Case Medical Center is participating in a Phase III clinical research study, called MINDSET, to evaluate the effectiveness of a potential new treatment option for people with mild-to-moderate Alzheimer’s disease.  The investigational drug, RVT-101, is being tested as an add-on therapy to donepezil (brand name Aricept®). Alan Lerner, MD, Director of the Brain Health and Memory Center at UH, is the principal investigator of the study in Cleveland.
MINDSET is an international, multi-center, double blind, placebo-controlled study designed to evaluate the safety, efficacy and tolerability of RVT-101.  The 24-week trial will compare RVT-101 to placebo in approximately 1,150 people with mild-to-moderate Alzheimer’s disease. All study participants will remain on donepezil therapy during the trial.  

Monday, June 20, 2016

Nicholas Bambakidis, MD, appointed Director of University Hospitals Neurological Institute

CLEVELAND – Neurosurgeon Nicholas Bambakidis, MD, has been appointed Director of the University Hospitals Neurological Institute (NI).  He will be responsible for the development and implementation of clinical operations strategy for the institute and will work with NI Co-director Anthony Furlan, MD, and Warren Selman, MD, Chairman of the Department of Neurological Surgery, on the growth of the institute system-wide.
Dr. Bambakidis will continue in his role as Director of Cerebrovascular and Skull Base Surgery.  He is recognized as an international leader in this field and has published more than 100 articles and book chapters as well as three textbooks.  He has led innovative initiatives related to intracerebral bypass surgery for the treatment of brain aneurysms and vascular malformations and neurointerventional endovascular surgery.  He is also Associate Professor of Neurosurgery at the Case Western Reserve University School of Medicine.

Monday, April 18, 2016

University Hospitals Case Medical Center first surgical site to test regenerative treatment for chronic stroke

CLEVELAND – University Hospitals Case Medical Center is the first surgical site for a Phase 2b clinical trial study to further evaluate the safety and efficacy of an investigational cell therapy for the treatment of chronic motor deficit following an ischemic stroke.
“With strokes, focus has been on prevention or treatment within the first few hours,” said Jonathan Miller, MD, Director of the Center for Functional and Restorative Neurosurgery at UH Case Medical Center, who performs the stem cell surgery as part of the study.  “Stroke is the leading cause of adult disability in the U.S., and there really hasn’t been much for this patient population.” 

Ischemic strokes account for approximately 87 percent of all strokes in the US and occur when there is an obstruction in a blood vessel supplying oxygen to the brain. With approximately 800,000 strokes occurring in the United States every year, stroke is the leading cause of acquired disability in the United States. Traditional stroke treatments generally show little or no improvement in patients after the first six months following a stroke.

Wednesday, February 24, 2016

Stroke patients show higher rate of recovery from MultiStem® cell therapy studied at University Hospitals Case Medical Center

CLEVELAND – Data presented by the biotech company Athersys indicates that stroke patients treated by an adult stem cell therapy called MultiStem® did significantly better than others who received a placebo one year after treatment.  The results are from a Phase 2 study involving clinical sites in the United States and the United Kingdom, including University Hospitals Case Medical Center. The study examined the safety and effectiveness of the new therapy developed for the treatment of ischemic stroke.  The data were presented Feb. 17 at the 2016 International Stroke Conference in Los Angeles.
Of the 65 patients treated with MultiStem®, 23.1 percent achieved a complete or near full recovery from their stroke after one year.  Only 8.2 percent of the 61 placebo patients achieved that level of recovery.  Patients who received the cell therapy within 36 hours after the onset of stroke did even better, with 29 percent of those 31 patients achieving an excellent outcome.
Cathy Sila, MD, Director of the Comprehensive Stroke Center at UH Case Medical Center, and Professor of Neurology at Case Western Reserve University, was the principal investigator of the study at UH Case Medical Center.

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