Researchers present findings on promising biomarker for esophageal cancer

Wednesday, May 07, 2014
CLEVELAND – A new biomarker for esophageal cancer shows promise in improving screening for this deadly disease and its precursor, Barrett’s esophagus.
 
Amitabh Chak, MD, of University Hospitals Case Medical Center’s Seidman Cancer Center and Case Western Reserve University School of Medicine, presented findings today at Digestive Disease Week in Chicago in a research forum titled “Aberrant Vimentin Methylation in Esophageal Brushings: A Biomarker for Detecting Barrett’s Esophagus and Esophageal Adenocarcinoma” (embargoed May 5, 9:15 am CT).
 
Dr. Chak and a research team found that a change in the DNA, methylation of the vimentin gene, can be an effective new less-invasive test for detecting Barrett’s esophagus (BE). In 117 patients, they examined if a new, non-endoscopic “brushing” of the esophagus is as effective as the more invasive, traditional biopsy.

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