UH Seidman Cancer Center investigators develop activated T cell therapy for advanced melanoma

Wednesday, July 08, 2015
CLEVELAND – T cells from patients with melanoma can trigger a protective immune response against the disease according to a new study out of University Hospitals Case Medical Center Seidman Cancer Center and Case Western Reserve University School of Medicine.
 
Published in the July/August issue of Journal of Immunotherapy, these new findings demonstrate that T cells derived from lymph nodes of patients with melanoma can be expanded in number and activated in the laboratory for intravenous administration in the treatment of patients.  Led by Julian Kim, MD, Chief Medical Officer at UH Seidman Cancer Center, the research team has developed a novel technique to generate large numbers of activated T cells which can be transferred back into the same patient to stimulate the immune system to attack the cancer.
 
“This study is unique in that the source of T cells for therapy is derived from the lymph node, which is the natural site of the immune response against pathogens as well as cancer,” says Dr. Kim who is also Professor of Surgery at Case Western Reserve University School of Medicine and the Charles Hubay Chair at UH Case Medical Center. “These encouraging results provide the rationale to start testing the transfer of activated T cells in a human clinical trial.”
t; font-family:"Arial","sans-serif"'>Anthem and UH announced in December 2014 a commercial Accountable Care Organization (ACO) designed to improve the overall quality of care while lowering the overall cost of health care. This new Accountable Care Organization for Medicare will leverage and expand upon the current relationship and market-leading infrastructure to coordinate care through high-quality providers to positively impact Anthem MA members’ health and wellness. The enhanced personal health care arrangement brings high-quality, patient-centered care to patients, and helps to control costs by promoting greater preventive care, enhanced care coordination and effective chronic disease management.
 
“University Hospitals is pleased to join with Anthem on this new accountable care arrangement that will enhance health services and improve coordination of care for Anthem’s Medicare Advantage members,” said Paul Tait, UH Chief Strategic Planning Officer. “As a national leader in population health management, we have had great success in improving health, enhancing quality of care, and managing costs for patients in our accountable care programs and we look forward to serving Anthem Medicare members.”

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