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Thursday, November 13, 2014

Harrington Discovery Institute at University Hospitals, Cleveland, forms affiliation with University of Oxford to create an International Initiative to Drive Early-Stage Drug Discovery and Development

CLEVELAND – The Harrington Discovery Institute at University Hospitals (UH) in Cleveland and University of Oxford (Oxford) in the United Kingdom announced today a newly formed affiliation that will leverage the academic medical centers’ combined expertise and resources to advance highly promising drug discovery projects.

“We are very honored to join forces with Oxford, a true global leader in research and discovery, to advance the most innovative treatments for human disease,” said Jonathan Stamler, MD, Director of the Harrington Discovery Institute. “Together we can more effectively enable a drug development model in academia that will move discoveries from the lab to the patient bedside.” 
 
The Harrington Discovery Institute, a nonprofit organization, formed in 2012 to help solve the decades-long global problem that drug researchers refer to as the “valley of death.” Universities continue to support research and early development of drugs. But pharmaceutical companies and venture investors who once supported the intermediate stages of development, now often wait until after a new drug’s effectiveness has been proven. That loss of support in the middle stages of drug development is a growing problem that has left many physician-scientists with no choice but to shelve some of their brightest ideas.  

Monday, November 10, 2014

UH Case Medical Center LEADLESS II trial part of worldwide effort to go wireless

CLEVELAND – Wireless is always better, but the transition into health care–specifically as it pertains to cardiology and pacemakers–is testing that theory.
 
University Hospitals (UH) Case Medical Center is among 60 worldwide sites studying a new leadless cardiac pacemaker system The device, called Nanostim and made by St. Jude Medical, is implanted using a minimally invasive procedure, delivered by a catheter through the groin, cutting implant time in half and decreasing recovery from four months to three days, all without an incision.
 
Almost 700 patients from across the globe, 50 percent from within the United States, will participate in the non-randomized clinical safety and effectiveness investigation called LEADLESS II.  In addition to testing the efficacy of the new device, the study will compare the newest technology against the traditional implant.

Thursday, October 30, 2014

Local researchers helping lead national study evaluating new approach that could slow progression of Alzheimer’s disease

CLEVELAND – University Hospitals (UH) Case Medical Center is participating in a new national Alzheimer’s disease (AD) clinical research study evaluating the potential benefits of an investigational medicine when taken by people with mild-to-moderate AD who are already being treated with donepezil (Aricept). Titled NOBLE, the trial is evaluating an investigational drug, T817MA, which may have the potential to modify the pace of the disease in those who are currently suffering with mild-to-moderate AD. 
 
The advent of NOBLE comes at a time when the AD clinical research community is moving to prevention-oriented trials that do not include people already diagnosed with the disease.  An estimated five million people in the United States already suffer from mild-to-moderate AD, with those numbers growing at an alarming rate. However, no new drug has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of AD since 2003. The NOBLE study was launched to potentially help address this gap in treatment.

Wednesday, October 29, 2014

Study finds knowledge poor about stroke in Uganda

CLEVELAND – A study published in the journal International Scholarly Research Notices (ISRN) Stroke found that overall knowledge about stroke in Uganda was poor, although knowing what to do for a stroke – go to the hospital – was good.
 
Researchers from higher education institutions in Uganda collaborated with those from Case Western Reserve and University Hospitals Case Medical Center to assess residents’ knowledge of stroke symptoms and treatment options. To date, public perception and level of knowledge of stroke warning signs and risk factors in Uganda have not been well studied, and researchers believe this is the first study to do so.  The researchers surveyed 1,600 residents, and found that three-quarters did not know any stroke risk factors and warning signs, or recognize the brain as the organ affected. 
 
“Main findings are that stroke knowledge is poor with some groups being particularly uninformed, individuals do not personally believe stroke is something that can actually happen to them, and few individuals see primary health care workers as a resource for stroke prevention or care,” the authors wrote.

Monday, October 27, 2014

University Hospitals Joins Focus on Flu – Public Awareness Campaign

CLEVELAND – While many Americans are fixated on the threat of Ebola, Cleveland’s health care community wants to remind people to protect themselves against a tangible threat that kills 3,000 to 49,000 Americans annually – influenza. University Hospitals has joined with the City of Cleveland and other local hospitals in a collaborative public awareness effort, Focus on Flu, aimed at educating residents about the importance of flu vaccinations. 
 
Unlike the common cold and many other viral respiratory infections, the flu can cause severe illness and life-threatening complications. It is estimated that in the U.S., each year on average 5% to 20% of the population gets the flu and more than 200,000 people are hospitalized from seasonal flu-related complications.

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